GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs12908161 | 1 | rs60957376 | chr15:85280792 | NMB | chr15:85198362-85201802:- | 0.36 | 7.73 | 6.62E-14 | Schizophrenia |
| THCA | cis | rs9902453 | 1 | rs60967688 | chr17:28437052 | ANKRD13B | chr17:27916801-27941778:+ | 0.33 | 8.2 | 2.17E-15 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs60967688 | chr17:28437052 | CORO6 | chr17:27941774-27948441:- | 0.48 | 11.62 | 1.19E-27 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs60967688 | chr17:28437052 | EFCAB5 | chr17:28256874-28435469:+ | 0.57 | 11.3 | 2.01E-26 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs60967688 | chr17:28437052 | GIT1 | chr17:27900487-27916610:- | 0.26 | 6.38 | 4.07E-10 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs60967688 | chr17:28437052 | LRRC37B2 | chr17:28903483-28992715:+ | 0.18 | 3.99 | 7.66E-5 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs60967688 | chr17:28437052 | SSH2 | chr17:27952965-28257018:- | 0.34 | 8.11 | 4.36E-15 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs60967688 | chr17:28437052 | TP53I13 | chr17:27895739-27900174:+ | 0.17 | 4.83 | 1.83E-6 | Coffee consumption (cups per day) |
| THCA | cis | rs9473555 | 1 | rs60982898 | chr6:49385806 | CENPQ | chr6:49431096-49460820:+ | -0.26 | -5.43 | 8.84E-8 | Folate pathway vitamin levels |
| THCA | cis | rs9473555 | 1 | rs60982898 | chr6:49385806 | MUT | chr6:49398994-49431031:- | 0.28 | 9.54 | 7.4E-20 | Folate pathway vitamin levels |
| THCA | cis | rs428445 | 1 | rs6099171 | chr20:55071253 | C20orf43 | chr20:55043647-55093942:+ | 0.28 | 7.58 | 1.84E-13 | Refractive astigmatism |
| THCA | cis | rs428445 | 1 | rs6099171 | chr20:55071253 | CSTF1 | chr20:54967427-54979582:+ | 0.17 | 3.49 | 0.000525 | Refractive astigmatism |
| THCA | cis | rs428445 | 1 | rs6099184 | chr20:55097478 | C20orf43 | chr20:55043647-55093942:+ | 0.28 | 7.47 | 3.82E-13 | Refractive astigmatism |
| THCA | cis | rs428445 | 1 | rs6099184 | chr20:55097478 | CSTF1 | chr20:54967427-54979582:+ | 0.17 | 3.5 | 0.000511 | Refractive astigmatism |
| THCA | cis | rs6099314 | 1 | rs6099314 | chr20:55454659 | CBLN4 | chr20:54572497-54580012:- | -0.21 | -3.57 | 0.000393 | Chronic obstructive pulmonary disease (moderate to severe) |